The incidence of diabetic skin ulcers is as high as 15%. Due to chronic hyperglycemia environment for a long time, the ulcer wound is easy to be infected, resulting in its failure to heal in time, and easy to form wet gangrene and amputation.
Skin wound repair is a highly ordered tissue repair project involving tissues, cells, extracellular matrix, cytokines and other factors. It is divided into inflammatory response stage, tissue cell proliferation and differentiation stage, granulation tissue formation stage and tissue remodeling stage. These three stages are different from each other and cross-cover each other, constituting a complex and continuous biological reaction process. Fibroblast is the foundation and key to promoting soft tissue injury repair, wound healing and preventing scar formation. It can secrete collagen, which can maintain the stable structure and tension of blood vessels, provide an important place for a variety of growth factors and cells to participate in the trauma response, and has a significant impact on the growth, differentiation, adhesion and migration of cells.
Inorganic induced active medical dressing organically combines bioactive glass and hyaluronic acid. PAPG matrix was used as the substrate to make full use of the characteristics of both. Bioactive glass, as an inorganic biosynthetic material, has unique surface activity, which can better regulate the function of wound cells and wound healing environment. It is an ideal biological material to promote wound healing, and can play a certain antibacterial role. Hyaluronic acid is one of the main matrix components of the epidermis and dermis of human skin. Its physiological functions are varied and its effect has been proved to be remarkable by clinical practice. The wound tissue is compatible with the dressing in a moist environment with the matrix, and the local water and electrolyte exchange is sufficient according to the principle of penetration, which is conducive to the growth and proliferation of fibroblasts, and can promote the formation of capillaries by adjusting the facial oxygen tension, thus accelerating wound healing.
The results showed that the wound healing time of the inorganic induced active medical dressing group was advanced, and there was no obvious bleeding, adhesion, scab or local allergy in the healing process, forming a stable stent and promoting scar free healing of the wound.
The experimental results indirectly suggested that the inorganic induced active medical dressing could increase the collagen content and reduce the proportion of collagen, which was beneficial to ulcer healing, reduce the degree of scar hyperplasia, and improve the healing quality of diabetic ulcer. In summary, the inorganic induced active medical dressing can accelerate the healing speed and improve the healing quality of diabetic ulcer, and its mechanism may be through promoting the proliferation of collagen and fibroblast in the damaged site, anti-infection, and improving the microenvironment of wound healing, so as to play a role. Besides, the dressing has good biological adaptability, no irritation to tissues, and high safety. It has broad application prospect.
HELTHSMILE MEDICAL will continue to innovate and provide users with efficient and convenient trauma repair products for HEALTH & SMILE.
Post time: Mar-02-2023